The invention belongs to the technical field of sealing and rust prevention, and particularly relates to a box body orifice sealing rust prevention method. The sealing rust prevention method comprisesthe following steps that an electric brush is used for grinding the surface layer of a hole opening of the box body, and a corrosion layer on the surface layer of the hole of the box body is removed;the hole of the box body is cleaned, wiped and dried; rust-proof oil is uniformly coated at the hole opening of the box body, and preliminary rust-proof treatment is performed on the hole opening ofthe box body, so that the sealing performance of the hole opening of the box body is influenced due to the fact that the hole of the box body is rusted; a sealing shell is attached to the hole openingof the box body, and a self-locking type core pulling rivet is fixed on the rivet hole through a pulling and riveting gun, so that the sealing shell and the box body are fastened permanently; and thesealing part and the rivet hole are filled with sealant, paint spraying treatment is carried out on the edge of the sealing shell and the self-locking type core-pulling rivet, and sealing and rust-proof treatment on the hole opening of the box body is completed. The sealing shell is fastened on the box body through the self-locking type core pulling rivet, so that the sealing performance of the hole opening of the box body is improved.