The invention discloses a tunneling blasting method comprehensively utilizing the detonator short time difference and an empty hole vibration reduction technique. The center line of a tunnel face of ablasted tunnel serves as the boundary, and the blasted area is divided into a left region and a right region, wherein the left region and the right region are symmetrical to each other; the two sidesof the center line are provided with a plurality of slotting holes, auxiliary holes and peripheral holes correspondingly, wherein the slotting holes, the auxiliary holes and the peripheral holes aresymmetrical to one another, a vibration reduction hole linear array is arranged on the ground between the blasted area and a building, and in the implementation process, the same row of holes are blasted hole by hole in a symmetrical and delayed manner. Hole-by-hole sequential blasting is performed through electronic detonators, and targeted to different types of blastholes, through the setting ofthe optimal delay time of the electronic detonators, vibration waves transferred to the ground interfere with one another and are counteracted partially; and meanwhile, vibration reduction holes of optimized design are formed on the ground, and 50% of blasting vibration can be effectively lowered. Through the combined measure, the blasting effect of a constructed smooth surface can be guaranteed,the defect that traditional smooth surface blasting is large in vibration can also be overcome, and finally influences on the surface buildings are reduced.