The invention discloses a long-distance large-diameter sealing pipeline system comprising a vacuum pipeline, an internal track, a supporting assembly, a vacuum pump system, vacuum monitoring equipment, a plurality of valves and a control system. The vacuum pipeline is of a cylinder structure with two closed ends and is composed of two or more vacuum pipe cylinder bodies which are connected througha corrugated pipe; the internal track is located on the upper portion of the supporting assembly, extends in the axis direction of the vacuum pipeline and used for operating of a train; the vacuum pump system, the vacuum monitoring equipment and the valves are used for controlling the vacuum degree in the vacuum pipeline; the vacuum pump system, the vacuum monitoring equipment and the valves aresubjected to signal transmission with the control system; the vacuum monitoring equipment is used for transmitting vacuum degree data of each vacuum pipeline section to the control system; and the control system controls the vacuum pump system and the corresponding valve to execute the corresponding action according to the received vacuum degree data of the vacuum monitoring equipment.