The invention relates to a fixation instrument for an internal fixation plate of the medical orthopedics department. The fixation instrument comprises a bottom plate, wherein a fixation supporting frame is installed on the bottom plate, a fixation containing frame is installed on the fixation supporting frame and symmetrically provided with fixation extrusion grooves, the fixation supporting frameis symmetrically provided with two fixation moving grooves, a moving mechanism is installed on the fixation supporting frame, and two extrusion mechanisms are installed on the moving mechanism. The fixation instrument can solve the problems that an existing internal fixation plate needs mutual fixation with the help of an existing clamp in the production process, mutual fixation of the internal fixation plate with the help of the existing clamp is unstable, the clamp needs to be adjusted manually according to different specifications of internal fixation plates, it is impossible to manually fix the internal fixation plate accurately with the help of the clamp, the internal fixation plate is prone to shaking in the machining process, and the machining accuracy of the internal fixation plate is affected.