The present invention discloses a screen printing machine, comprising a frame on which an unwinding device, an printing device, two storing devices and a winding device arranged, wherein the storing device is arranged on two sides of the printing device, and the winding device and the unwinding device is respectively arranged on two ends of the frame; the printing device includes a sliding box, two positioning components, a walking component, a blade coating component, and a driving component, wherein the sliding box could be arranged on the frame for horizontal sliding, on which the walking component, the blade coating component, and the driving component are arranged, and below which the positioning component which provide power for the walking component and the blade coating component is symmetrically arranged. According to the invention, the screen printing machine is able to simultaneously carry out the horizontal movement of the printing device and the blade coating action through one power, which saves energy, and optimizes the structure. The continuous execution of unwinding, printing, and winding can be guaranteed with the arrangement of the storing device, which improvesthe effectiveness of printing.