The invention discloses a method of simulating the specific nonlinear wave sequence. The method includes preprocessing of the ocean measured wave sequence, accurate solution of the nonlinear dispersion relation and automatic generation of wave machine driving signals. According to the method, the observed ocean wave sequence can be automatically processed, the wave sequence obtained through oceanobservation is converted into the frequency, the corresponding amplitude and the phase information required for laboratory simulation waves according to the Froude number similarity criterion throughutilizing Fourier transform; the third-order nonlinear irregular wave interaction theory is utilized to rapidly calculate the dispersion relation of complex multi-frequency waves through the iterativecalculation method, generally, wave number accuracy of wave components can be calculated to one thousandth within ten iteration steps, and problems of low precision and long time for directly solvingthe nonlinear dispersion relation are solved.