The invention discloses a foot sole rehabilitation pressing device. The foot sole rehabilitation pressing device comprises a base, a foot cover and a power source; the base is of a square structure with a cavity, the foot cover comprises bottom plates and fixing belts, the bottom plates and the fixing belts are closely attached to the foot soles of a patient, and the bottom plates are fixed to thebase and provided with multiple through holes corresponding to the acupuncture points of the foot soles; the foot cover further comprises multiple pressing blocks matched with the through holes, andthe power source is connected with all the pressing blocks separately, and independently makes liquid injected into or drawn out of all the pressing blocks to make the pressing blocks penetrate through the through holes or draw back. In this way, by means of the foot sole rehabilitation pressing device, the foot soles of the patient can be pressed, and blood circulation of the patient is promoted;meanwhile, it is easy for the patient to operate the device, and convenient for the patient to use the device.