The invention relates to an extrusion forming method of a main nuclear power pipeline provided with pipe orifices. The extrusion forming method comprises the following steps that 1, an extrusion device is prepared; 2, a preformed blank is prepared; 3, a hollow pipe blank is prepared, wherein a relay punch is utilized to extrude the center of the preformed blank to form a central hole, the hollow pipe blank is formed and comprises a pipe body and actual and redundancy pipe orifices arranged on the pipe body, the redundancy pipe orifice and the actual pipe orifice are symmetric with respect to the axis of the pipe body, the actual pipe orifice comprises an actual oblique pipe orifice and an actual straight pipe orifice, and the actual oblique pipe orifice and the actual straight pipe orificeare connected to form an integral structure; 4, a forge piece is prepared; 5, the redundancy pipe orifice on the forge piece is removed. The process is simple, the process quality is stable, and theweight of electroslag ingots can be decreased. The invention also relates to the main nuclear power pipeline provided with the pipe orifices. The oblique pipe orifice and the straight pipe orifice areconnected to form the integral structure, and the process feasibility of mold manufacture can be improved.