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CN108822019A 一种检测脂滴极性的荧光探针及其制备方法和应用 失效 - 权利终止

  • Patent Title: 一种检测脂滴极性的荧光探针及其制备方法和应用
  • Patent Title (English): Fluorescent probe for detecting polarity of lipid droplets and preparation method and application thereof
  • Application No.: CN201810953564.5
    Application Date: 2018-08-21
  • Publication No.: CN108822019A
    Publication Date: 2018-11-16
  • Inventor: 林伟英 , 阴军玲 , 彭敏
  • Applicant: 济南大学
  • Applicant Address: 山东省济南市市中区南辛庄西路336号
  • Assignee: 济南大学
  • Current Assignee: 济南大学
  • Current Assignee Address: 山东省济南市市中区南辛庄西路336号
  • Agency: 济南泉城专利商标事务所
  • Agent 李桂存
  • Main IPC: C07D209/86
  • IPC: C07D209/86 ;  C09K11/06 ;  G01N21/64
一种检测脂滴极性的荧光探针及其制备方法和应用
Abstract:
本发明提供了一种检测脂滴极性的荧光探针，化学名称为3-（4-（2,2-二氰基乙烯基）苯基）-9-乙基咔唑，结构式为 ；由于该探针存在分子内扭曲电子转移效应（TICT），从而实现对溶剂极性的良好响应。本发明的荧光探针整体为电中性，可以使其很好的定位在细胞内的脂滴中。该探针能准确的定位于脂滴，具有较高的灵敏度，良好的光学稳定性以及对极性特异性响应；并且实现了对细胞内脂滴极性的检测。该探针的合成方法，步骤简单、纯化方便、收率高。
Abstract(English):

The invention provides a fluorescent probe for detecting the polarity of a lipid droplet. The chemical name is 3-(4-(2,2-dicyanylvinyl)phenyl)-9-ethylcarbazole, and the structural formula is as shownin the specification. Due to the intramolecular distorted electron transfer effect (TICT) of the probe, a good response to solvent polarity is achieved. The fluorescent probe of the invention is electrically neutral, and can be well positioned in lipid droplets in cells. The probe can be accurately located in lipid droplets, has high sensitivity, good optical stability and specific response to polarity, and achieves detection of polarity of lipid droplets in cells. A method for synthesizing the probe has the advantages of simple steps, convenient purification and high yield.

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