A method for simulate a radio frequency circuit and a related device are disclosed, The method is used for simulating a radio frequency circuit including a radio frequency transceiver, a power amplifier PA, a duplexer, a first low noise amplifier LNA, a second LNA, a filter, a diversity switch, a diversity antenna, a master switch and a master antenna. The method includes assuming a first impedance value of a port of the duplexer adjacent to the first LNA; assuming a second impedance value at the input of the first LNA; establishing a first two-port network model, wherein a first port of the first two-port network model is used as an input terminal of the first LNA, and a second port of the first two-port network model is used as an output terminal of the duplexer; on the premise that thefirst two-port network model satisfies impedance matching, simulating the first two-port network model to obtain the first matching network. The embodiment of the present application is adopted, the simulation efficiency can be improved.