The invention discloses a drilling and milling processing system with a function of rotating and pressing a workpiece, and belongs to the field of drilling and milling processing devices. The drillingand milling processing system comprises rotating and pressing mechanisms, a workbench mechanism, a drilling and milling mechanism, and chip removal mechanisms arranged at two sides of the workbench mechanism respectively, wherein the workbench mechanism comprises a rotating table, a plurality of telescopic cylinders are arranged on the upper top surface of the rotating table, and the central axisof an output shaft of the telescopic cylinder passes through the center of a circle on the upper top surface of the rotating table; an arc plate is arranged at the end of the output shaft of the telescopic cylinder; the drilling and milling mechanism comprises a base which is arranged above a transmission box, a frame is arranged on the base, and a drilling and milling machine is arranged on theframe; the drilling and milling machine comprises a self-cooling drill bit; and a plurality of rotating and pressing mechanisms are arranged on the top surface of the rotating table, and the rotatingand pressing mechanism comprises an outer cylindrical body, a bearing seat and a pressing plate. The drilling and milling processing system has a high integration level.