The invention provides a multi-cell cellular network interference alignment method based on a full-duplex base station, aiming at improving the system capacity of the multi-cell cellular network system. Select a user group; constructing an interference alignment matrix, a decoding matrix and a receiving matrix; an uplink us transmits an uplink signal of a first time slot, a base station decode that uplink signal of the first time slot, and simultaneously transmits a downlink signal of the first time slot; an uplink us sends an uplink signal of a second time slot and a base station send a downlink signal of that second time slot. The acquisition of that decode signal by the downlink user. A full duplex base station is used in each cell, An uplink us and a base station respectively transmitsignals to a base station and a downlink us through two time slots, Moreover, the base station of each cell and the base stations of neighboring cells jointly transmit and decode signals, thereby effectively eliminating the uplink/downlink interference and the inter-cell interference of the multi-cell full-duplex communication, and improving the system capacity compared with the prior art.