中科微点-全球专利检索

  1. Login
  2. Sign Up
Invention Publication
CN109554461A 一组检测原发性HLH的生物标记及其检测试剂盒 有权

一组检测原发性HLH的生物标记及其检测试剂盒
Abstract:
本发明提供了一组检测原发性HLH的生物标记及其检测试剂盒，涉及分子生物学技术领域。检测原发性HLH的生物标记为突变基因群，包括PRF1、UNC13D、STX11、STXBP2、SH2D1A、XIAP、ITK、CD27、MAGT1、RAB27A、LYST、AP3B1、BLOC1S6、TCN2、IL2RG共15个基因的突变基因的集合，其外显子区域共携带411个突变位点。检测原发性HLH试剂盒包括用于扩增原发性HLH的突变基因群中突变基因的引物。该试剂盒具有检测效率高、突变基因覆盖面广、检出率高等优点，使用该检测试剂盒所给出的医学解读报告更加准确、权威。
Abstract(English):

The present invention provides a set of biomarkers for detecting primary HLH and a detection kit thereof, and relates to the technical field of molecular biology. The biomarkers for detecting the primary HLH are a mutated gene group including a set of mutation genes of a total of 15 genes of PRF1, UNC13D, STX11, STXBP2, SH2D1A, XIAP, ITK, CD27, MAGT1, RAB27A, LYST, AP3B1, BLOC1S6, TCN2, and IL2RGand exon regions carry a total of 411 mutation sites. The detection kit for detecting the primary HLH comprises primers used for amplifying primers of the mutation genes in the mutated gene group of the primary HLH. The kit has advantages of high detection efficiency, wide coverage of the mutation genes, high detection rate, etc. Medical interpretation reports given by the detection kit are more accurate and authoritative.

Public/Granted literature
Patent Agency Ranking
0/0