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Invention Grant
CN109575134B 异嗜性抗体阻断剂HBR-6及其制备方法 有权

异嗜性抗体阻断剂HBR-6及其制备方法
Abstract:
本发明提出一种异嗜性抗体阻断剂HBR‑6，包括其可变区的氨基酸序列和核苷酸序列，其中，重链的3个互补决定区CDR序列分别为，CDR1：Phe‑Thr‑Ala‑Asp‑Thr‑Ser‑Ser，CDR2：Glu‑Asp‑Asp‑Pro，CDR3：Val‑Leu‑Asp‑Ser‑Asp‑Gly‑Ser‑Tyr；轻链的3个互补决定区CDR序列分别为，CDR1：Asn‑Ile‑Pro‑Lys‑Leu‑Leu‑Ile‑Tyr，CDR2：Ile‑Val‑Met‑Thr，CDR3：Gln‑Gly‑Glu‑Asp‑Ile‑Ala‑Thr‑Tyr‑Arg，具备良好的亲和性。同时本发明还提出了异嗜性抗体阻断剂HBR‑6的制备方法。
Abstract(English):

The invention provides a heterophilic antibody blocker HBR-6. The heterophilic antibody blocker HBR-6 comprises an amino acid sequence and a nucleotide sequence in a variable region of the heterophilic antibody blocker HBR-6, wherein the sequences of three complementary determining regions (CDR) of a heavy chain are respectively CDR1 being Phe-Thr-Ala-Asp-Thr-Ser-Ser, CDR2 being Glu-Asp-Asp-Pro, and CDR3 being Val-Leu-Asp-Ser-Asp-Gly-Ser-Tyr; and the sequences of three CDRs of a light chain are respectively CDR1 being Asn-Ile-Pro-Lys-Leu-Leu-Ile-Tyr, CDR2 being Ile-Val-Met-Thr, and CDR3 beingGln-Gly-Glu-Asp-Ile-Ala-Thr-Tyr-Arg, and good affinity is achieved. Meanwhile, the invention further provides a preparation method of the heterophilic antibody blocker HBR-6.

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