The invention provides a simulation system for high-frequency flutter disturbance optical TDI camera imaging. The simulation system comprises an air floating high-frequency measuring table, an executing mechanism, an executing mechanism controller, a dynamic target, an imaging simulation source, a TDI CCD camera and a computer, wherein the executing mechanism is arranged on the air floating high-frequency measuring table; the executing mechanism controller is used for setting the preset rotating speed of the executing mechanism, and the executing mechanism runs at a high speed on the air floating high-frequency measuring table; a flutter sensor is used for collecting and outputting flutter data to the imaging simulation source; the TDI CCD camera is kept to be fixed, the dynamic target carries out one-dimensional motion on a vibration isolation table, and an ideal target image is collected by the TDI CCD camera; the imaging simulation source outputs a target image of the mixed high-frequency flutter; and the computer performs image quality comparison analysis. According to the simulation system, the high-frequency flutter curve generated by the satellite on-orbit flight is simulated, the imaging disturbance of the high-resolution camera is simulated through different amplitudes and frequencies of the simulation execution mechanism, and further the support is provided for analyzing how high-frequency TDI CCD camera imaging is disturbed by analyzing an on-satellite high-frequency flutter environment.