The invention discloses a QR code vandal-resistant device of an automatic vending machine. The device comprises a ventilator, a fan cabinet, a QR code, projection lamps, a suspender, a camera, a camera protective cover, a signal line, an instrument panel, a control line, a system operation end, a display screen, an operation terminal, a power supply port, a blow-off pipe, limiting blocks, a piezoelectric sensor, pulleys, a delivery box, a vending cabinet and guide rails; and the ventilator is arranged on the fan cabinet. The QR code is adhered by adopting a paper sticking way; the camera can update the QR code at fixed time, and can obtain an instruction to call a camera to shoot so as to acquire information of lifting personnel and/or shielding personnel; and meanwhile, a user is prevented from scanning the maliciously damaged QR code, and the normal scanning use of the user cannot be influenced; the device can project caution slogan to remind the user to notice the accurate QR code,thereby effectively maintaining the normal running of the vending machine.