The invention provides an e-commerce logistics infrared radiation hot melting sealing box. The e-commerce logistics infrared radiation hot melting sealing box comprises a box body; an opening is formed in the top of the box body, and is provided with a box cover; the box cover comprises main box covers positioned on two opposite edges in the opening, and secondary box covers positioned on other two opposite edges in the opening; the two secondary box covers can be overturned to the opening to level with the opening; the two main box covers can be overturned to the opening to reach above the secondary box covers and close the whole opening; when the two main box covers cover the secondary box covers, main hot melting adhesive tapes are arranged on the surfaces, towards the secondary box covers, of the main box covers and on the sides near the other main box covers; when the two secondary box covers cover the opening, secondary hot melting adhesive tapes opposite to the main hot meltingadhesive tapes are arranged on the surfaces of the main box covers towards the upper sides of the secondary box covers; and the main hot melting adhesive tapes and the secondary hot melting adhesive tapes are bonded through infrared heating pipe heating. The e-commerce logistics infrared radiation hot melting sealing box has the advantages of convenience to automatically seal, firm fixation, safety, reliability and convenience to unpack.