The invention discloses a fault isolation positioning system. The fault isolation positioning system comprises a first circuit breaker module, a second circuit breaker module and a monitoring module,wherein the first circuit breaker module and the second circuit breaker module are arranged on the two sides of the system, and the monitoring module is connected with the first circuit breaker moduleand the second circuit breaker module; and when a current signal is detected, the first circuit breaker module and the second circuit breaker module mutually transmit a carrier signal, and send an alarm signal with position information to the monitoring module when the carrier signal fed back by the second circuit breaker module is not received. Compared with the prior art, carrier signal mutualtransmission and detection are carried out through the first circuit breaker module and the second circuit breaker module, so that whether a direct current bus fails or not is judged, and the circuitfault judgment is simple and efficient; a fault line is isolated from the system when the fault occurs, and the safety of power supply is guaranteed; and an alarm signal with fault position information is sent to a monitoring terminal, so that the positioning and isolation of the fault position are realized.