The invention relates to the technical field of computers, in particular to a computer chassis vibration resisting device. The computer chassis vibration resisting device comprises a support base; thesupport base is provided with a placing tank for placing a chassis; multiple damping and supporting modules for supporting and damping the chassis are symmetrically arranged on the left and right sides of the placing tank; and a ventilation and heat dissipation mechanism is arranged at the middle part of the placing tank. The computer chassis vibration resisting device is novel in structure and reasonable in design, achieves better clamping, self-locking, fixation, vibration resisting, ventilation and heat dissipating effects on the chassis, and facilitates both popularization and application.