The invention provides a passage switchable type air purification sterilization machine. The passage switchable type air purification sterilization machine comprises a first shell body and a second shell body, wherein the first shell body is internally provided with a first air inlet, a second air inlet and a first middle through hole, the first middle through hole is internally provided with HEPApurifiers and full heat exchange filter elements, the first air inlet communicates with the first middle through hole through a first bent passage, and the second air inlet communicates with the first middle through hole through a second bent passage; and the second shell body is internally provided with a first air fan, a second air fan and a second middle through hole, the second middle throughhole communicates with the first middle through hole, the first air fan communicates with the second middle through hole through a first air pipe, and the second air fan communicates with the secondmiddle through hole through a second air pipe. According to the passage switchable type air purification sterilization machine, by means of adoption of the arrangements of the first bent passage and the second bent passage, purification is controlled to be more thorough; and by means of the adoption of the arrangements of the first air pipe and the second air pipe which are of different hole diameters, the flow speed of sprayed air is reduced, and the passage switchable type air purification sterilization machine is more suitable for use.