The invention discloses a method for formulating the grade of an intra-regional environmental sanitation operation road. The method comprises the steps that step 1,acquiring national road data and national road surrounding interest point data from navigation electronic map data according to administrative regions; step 2, judging national road data and national road surrounding interest point databy using a preset environmental sanitation operation road grade level, marking roads in the national road data as corresponding environmental sanitation operation road grades, and storing the environmental sanitation operation road grades in an environmental sanitation operation road grade database; step 3, selecting road data in an area from the navigation electronic map data; and step 4, determining the environmental sanitation operation road grade of the road data in the selected area from the environmental sanitation operation road grade database, and outputting the environmental sanitation operation road grade in a graded manner according to the environmental sanitation operation road grade. According to the method, the grade of the sanitation operation road is judged and determinedthrough the navigation electronic map data, independent measurement for determining the grade of the sanitation operation road is not needed, the measurement workload is reduced, measurement errors are avoided, and meanwhile data can be conveniently updated at regular time.