The invention discloses a ship design profile nesting method. The method comprises the following steps: 1, starting a profile nesting program; 2, reading data of a Manufacture database, and storing the data in the Manufacture database; 3, generating profile base material data according to the profile part data, 4, selecting whether base metal data needs to be modified or not according to actual requirements; 5, when base metal data needs to be modified; 6, starting automatic typesetting; 7, selecting whether interactive modification is needed or not according to actual conditions; 8, performing interactive modification; 9, after finishing modifying the nesting data, storing the trepanning data and writing the nesting data back; 10, outputting a nesting diagram. According to the method, anadvanced algorithm is used for improving the material utilization rate, an interactive modification function is provided, a nesting result can be presented in the form of a drawing to be used by a production department, and the manufactured nesting image precision is higher, and the fault-tolerant rate is higher.