The invention discloses a driving method of a power driving module, the power driving module and a display device. The driving method comprises the steps of obtaining load information; judging the load information, if the load is increased, controlling the switching frequency of a switch module of the power supply driving module to be increased, and improving the power supply output of the power supply driving module; when the load is decreased, controlling the switching frequency of the switch module of the power driving module to be reduced, and reducing the power output of the power drivingmodule. When the rear-end load of the power supply driving module is increased, the switching frequency of the switch module is improved through control, so that the response to the rear-end load isfaster, the power supply can quickly compensate the voltage level through recharging, and the ripple wave of the voltage is reduced; when the rear-end load of the power supply circuit is reduced, thevoltage of the rear-end load is reduced by controlling and reducing the switching frequency of the switch module, so that the power loss of the rear-end load is reduced, and the electromagnetic radiation of the power supply driving module is also reduced along with the reduction of the power.