A method of a chronic disease management path based on big data comprises the following steps of 1, performing modeling on a chronic disease management path core task content based on a body and a rule; finishing establishment of a chronic disease management body according to a selected body expression language and a modeling tool, defining a whole concept, relations and example expressions in thechronic disease management body as a knowledge base for path executable expression; wherein a designing rule comprises a process and requirement of executable expression; and 2, designing a service engine architecture and applying the service engine architecture in actual chronic disease management; finishing instantiation of the chronic disease body and finishing path establishment and rule expression of various chronic disease management tasks; based on a rule file, designing and realizing an executable chronic disease management path standard interface server, and realizing application andimprovement of a chronic disease management path modeling method in a chronic disease management operation platform; and 3, evaluating an application effect.