The invention discloses an aluminum substrate full-glue pressing method capable of replacing resin hole plugging, and the method comprises the following steps: S1, material cutting: selecting an aluminum substrate in a preset size, fixing the aluminum substrate, and performing drilling; S2, high-temperature adhesive pasting: pasting a high-temperature adhesive on the surface of the drilled aluminum substrate; S3, adhesive laser cutting: performing the adhesive laser cutting of the aluminum substrate pasted with the high-temperature adhesive, performing windowing at the position where the holeplugging is needed, and enabling a through hole to be exposed; S4, stacking: stacking PP sheets on the upper surface and the lower surface of the windowing position; S5, pressing: filling the throughhole filled with the melted PP sheets under the vacuum high-pressure environment, and stripping the high-temperature glue after pressing; S6, resin grinding: grinding the surface of the stripped aluminum substrate through a resin grinding machine in the alternate of the transverse direction and the vertical direction, and removing the resin on the surface so as to guarantee that no adhesive residue exists on the surface of the aluminum substrate. The method can completely ensure the resin plugging fullness of the hole, meets the requirement for secondary drilling of the plugged hole site corresponding to a pressed finished plate, and is simple, practical, high in production efficiency and low in cost.