A transparent resin substrate which sequentially comprises, on a light-transmitting resin substrate sheet, a base layer, a hard coat layer and an antireflection film that contains a medium refractiveindex layer and a low refractive index layer. The base layer is composed of a cured product which is obtained by curing (A1) a hexa- or higher functional urethane acrylate monomer; the hard coat layeris composed of a cured product which is obtained by curing a composition that contains (A) a polymerizable monomer containing 50% by mass or more of (A2) a tri- or lower functional urethane acrylatemonomer, (B) silica particles, (C) a silane coupling agent and (D) a metal chelate compound; the medium refractive index layer is composed of a cured product which is obtained by curing a compositionthat contains (E) an organic-inorganic composite resin, (F) metal oxide particles, (C) a silane coupling agent and (D) a metal chelate compound; and the low refractive index layer is composed of a cured product containing no particles, which is obtained by curing a composition that contains (G) a silicon compound represented by Rn-Si(OR)4-n, (C) a silane coupling agent and (D) a metal chelate compound. This transparent resin substrate is suppressed in cracking, and is useful as an antireflection film for insert molding.