The present disclosure is directed to methods and systems for calibration, calibration verification, and sensitivity checks for a detector. The methods and systems include calibrating a detector by releasing at least one calibrant from at least one calibrant chamber in flow communication with the detector. The systems and methods further include verifying the calibration by releasing at least oneverification substance from at least one verification chamber in flow communication with the detector. The systems and methods further include checking a sensitivity of the detector by releasing at least one sensitivity substance from at least one sensitivity chamber in flow communication with the detector.