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CN110325649A 用于筛选羟基类固醇(17-β)脱氢酶(HSD17B)家族成员的调节剂的活性的测定法 无效 - 撤回

用于筛选羟基类固醇(17-β)脱氢酶(HSD17B)家族成员的调节剂的活性的测定法
Abstract:
本发明提供了用于鉴定羟基类固醇(17-β)脱氢酶(HSD17B)家族成员蛋白诸如HSD17B13的调节剂的筛选方法以及试剂盒。所述方法包括筛选分子调节所述HSD17B家族成员蛋白，包括抑制所述HSD17B家族成员蛋白的能力，如通过底物耗减、来自所述HSD17B家族成员蛋白底物转化的产物浓度或NADH浓度、标记底物的水平、荧光素光发射或它们的组合来测量。通过所述筛选方法鉴定的HSD17B家族成员蛋白的抑制剂可以用于治疗其中所述HSD17B家族成员蛋白发挥作用的肝脏疾病、病症或疾患。
Abstract(English):

Screening methods as well as kits for identifying modulators of hydroxysteroid (17-beta) dehydrogenase (HSD17B) family member proteins, such as HSD17B13, are provided. The methods comprise screening molecules for their capacity to modulate the HSD17B family member protein, including inhibiting the HSD17B family member protein, as measured by substrate depletion, product concentration from the HSD17B family member protein substrate conversion or NADH concentration, levels of labeled substrate, luciferin light emission, or combinations thereof. Inhibitors of HSD17B family member proteins identified through the screening methods may be used to treat liver diseases, disorders, or conditions in which the HSD17B family member protein plays a role.

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