The invention relates to a compactly arranged 220kV all-indoor transformer substation. The transformer substation comprises a building, a plurality of main transformer units, 220V/110kV gas-insulatedmetal-enclosed switchgear, a 10kV switch cabinet, a 10kV arc suppression coil grounding transformer sleeve device and secondary equipment. The interior of the building is divided into a first space, asecond space and a third space in the Y-axis direction of the rectangular coordinate system, the second space is further divided into a first subspace and a second subspace, and the third space is further divided into a third subspace and a fourth subspace. The main transformer units are arranged in the first space; the secondary equipment is arranged in the first subspace; the 10kV switch cabinet and the 10kV arc suppression coil grounding transformer sleeve device are arranged in the second subspace; the 220kV gas-insulated metal-enclosed switchgear is arranged in the third subspace; and the 110kV gas-insulated metal-enclosed switchgear is arranged in the fourth subspace. The total occupied area of the transformer substation can be reduced, and equipment arrangement is more compact andreasonable.