The invention discloses a compression-resistant crease-resistant non-ironing shirt. The skirt comprises a skirt body, a collar body and sleeve bodies, wherein the skirt body comprises a front piece body, shoulder empiecements and a rear piece body; strip-shaped supporting frameworks I are arranged along the edges of the shoulder empiecements; the front piece body comprises a top fly and an under fly; long strip-shaped sheet supporting frameworks II are arranged in the top fly and the under fly; side seams are arranged at the joint of the front piece body and the rear piece body; long strip-shaped supporting frameworks III in a length direction of the shirt body are arranged in the side seams; muffs are arranged at the joints of the sleeve bodies and the skirt body; annular supporting frameworks IV are arranged in the muffs; sleeve bottom seams are arranged on one sides of the sleeve bodies relative to the skirt body; and long strip-shaped supporting frameworks V in the length directions of the sleeve bodies are arranged in the sleeve bottom seams. The supporting frameworks are buried at the joints of all the parts of the shirt body based on the structural mechanics and kinematics of a human body, so that the shirt has relatively good stereoscopic impression, crease resistance and tensile deformation resistance during wearing; and meanwhile, the support of the frameworks can achieve the effects of modifying the symmetry of the human body and covering the body shape defects of a wearer.