The invention discloses a minimally invasive endoscopy cutting anastomat with exchangeable assemblies, and relates to the technical field of medical apparatuses. The minimally invasive endoscopy cutting anastomat comprises a anastomat housing, wherein a fixing handle is mounted at the bottom end of the anastomat housing; a handle protective sleeve coats the fixing handle; a transmission mechanismis mounted in the anastomat housing; a first rolling shaft is connected to the bottom end of the transmission mechanism; a moving handle is connected to the outer wall of the first rolling shaft; anda fixing mechanism is mounted on one side of the transmission mechanism, and a cutting knife is mounted on the other side of the transmission mechanism. According to the minimally invasive endoscopy cutting anastomat disclosed by the invention, a pressing head is pressed, so that disinfecting liquid in a disinfecting liquid cup can flow through a duct to enter absorbent cotton; and the cutting knife is coated with the absorbent cotton, and the cutting knife can be disinfected by the absorbent cotton, so that when the minimally invasive endoscopy cutting anastomat is used, a user cannot additionally disinfect the cutting knife, the working efficiency of the anastomat is improved, and the working safety of anastomosis is improved.