The invention provides a noise reduction method and device, a mobile terminal and a storage medium, the noise reduction method is applied to the mobile terminal, the mobile terminal comprises a soundacquisition module and a playing module, and the method comprises the following steps: acquiring an environmental noise signal through the sound acquisition module; according to the environment noisesignal, obtaining the environment noise signal of the position of a playing module through a preset rule; carrying out subtraction processing on the audio signal to be played and an environment noisesignal at the position of a playing module; and playing the audio signal subjected to subtraction processing through the playing module. After the technical scheme is adopted, the mobile terminal onlyneeds to be provided with one microphone to realize noise reduction without additionally arranging the microphone, so that the cost of the mobile terminal is reduced, and the structure of the mobileterminal is simplified.