The invention relates to the technical field of security protection tail box cabinets, and discloses a security protection tail box cabinet and a security protection tail box cabinet handover method.The security protection tail box cabinet comprises a cabinet body, a cabinet door arranged on the obverse side of the cabinet body and a control cabinet arranged in the cabinet body, wherein a touch screen controlled by a control host computer is arranged on the control cabinet, the cabinet body comprises a plurality of storage boxes used for storing tail boxes and lengthways arranged, RFID (radiofrequency identification) readers used for reading identity information of the tail boxes are arranged in the storage boxes, each storage box comprises a box door arranged on the obverse side of eachstorage box, and an electronic control lock and a handle are arranged on each box door. The security protection tail box cabinet and the security protection tail box cabinet handover method simplifysteps of placing the tail boxes in the cabinet body, are convenient and quick to operate, and improve work efficiency of staffs.