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Invention Publication
CN110819342A 一种上转换纳米颗粒、载药纳米颗粒及其制备方法和应用 审中-实审

一种上转换纳米颗粒、载药纳米颗粒及其制备方法和应用
Abstract:
本发明提供一种上转换纳米颗粒、载药纳米颗粒及其制备方法和应用，该上转换纳米颗粒为核-壳-壳结构，其分子式为CaF2:Yb3+/Er3+@NaGdF4:Yb3+@NaGdF4，简称为UCNPs，其中，CaF2:Yb3+/Er3+为核，CaF2:Yb3+/Er3+@NaGdF4:Yb3+为核壳，CaF2:Yb3+/Er3+@NaGdF4:Yb3+@NaGdF4为核壳壳，其粒径小、荧光强，在其表面加载RBHA以及DSP，构建多功能单纳米粒子的诊断治疗平台UCNPs-RBHA-Pt，可用于抑制肿瘤细胞和组织的增殖和生长。
Abstract(English):

The invention provides an up-conversion nanoparticle and a drug-loaded nanoparticle, and preparation methods and an application thereof. The up-conversion nanoparticle is of a core-shell-shell structure and has a molecular formula of CaF<2>: CaF<2>Yb<3+>/Er<3+>@NaGdF<4>: Yb<3+>@NaGdF<4> (UCNPs for short), wherein CaF<2>: CaF<2>Yb<3+>/Er<3+> is a core, CaF<2>: CaF<2>Yb<3+>/Er<3+>@NaGdF<4>: Yb<3+> is a core-shell, and CaF<2>: CaF<2>Yb<3+>/Er<3+>@NaGdF<4>: Yb<3+>@NaGdF<4> is a core-shell-shell. The up-conversion nanoparticle is small in particle size and strong in fluorescence; RBHA and DSP are loaded on the surface of the up-conversion nanoparticle to construct a diagnosis and treatment platform UCNPs-RBHA-Pt for multifunctional single nanoparticles, and can be used for inhibiting proliferation and growth of tumor cells and tissue.

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