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Invention Publication
CN112384513A GABAA正变构调节剂化合物、其制备方法和用途 审中-公开

GABAA正变构调节剂化合物、其制备方法和用途
Abstract:
本文描述了包含2’,6‑二氟‑5’‑[3‑(1‑羟基‑1‑甲基乙基)‑咪唑并[1,2‑b][1,2,4]三嗪‑7‑基]联苯基‑2‑甲腈(TPA023B)或其盐的多晶型物。一方面，本文披露了TPA023B与磷酸的结晶多晶型盐或共晶体。本文还描述了其制备和使用方法。
Abstract(English):

Described herein are polymorphs comprising 2′,6-difluoro-5′-[3-(1-hydroxy-1-methylethyl)-imidazo[1,2-b][1,2,4]triazin-7-yl]biphenyl-2-carbonitrile (TPA023B) or salts thereof. In one aspect, disclosed herein is a crystalline polymorphic salt or co-crystal of TPA023B with phosphoric acid. Also described herein are methods of making and using the same.

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