The utility model relates to an amoxicillin long-acting granular pill comprising a base pill 1 as a center, a medicine layer 2 formed by mixing amoxicillin, direactive glyceride, HPMC and acrylics, apolymer slowly-releasing coating layer 3 and a color-coat layer 4, wherein the medicine layer 2 is coated on the base pill 1, and the polymer slowly-releasing coating layer 3 and the color-coat layer4 are used for orderly coating outward layer by layer. The amoxicillin long-acting granular pill solves the problem of short amoxicillin half decay period and many pill feeding times, and makes up thedisadvantages of the prior art.