Invention Grant
- Patent Title: Biocompatible tissue graft
-
Application No.: US14837658Application Date: 2015-08-27
-
Publication No.: US10004586B2Publication Date: 2018-06-26
- Inventor: Kathleen Anne Derwin , Anthony Calabro
- Applicant: The Cleveland Clinic Foundation
- Applicant Address: US OH Cleveland
- Assignee: The Cleveland Clinic Foundation
- Current Assignee: The Cleveland Clinic Foundation
- Current Assignee Address: US OH Cleveland
- Agency: Pearne & Gordon LLP
- Main IPC: A61F2/02
- IPC: A61F2/02 ; A61F2/00 ; A61L27/36 ; A61L27/52 ; A61L27/34 ; A61L31/10 ; A61L31/14

Abstract:
Biocompatible tissue grafts are provided. The biocompatible tissue grafts include a bulk graft including a biocompatible material and having at least a first surface. The biocompatible tissue grafts also include a coating including a hydrogel and being immobilized on the bulk graft at the first surface. The biocompatible material includes at least one of a biologic material or a biologic-synthetic composite material. The hydrogel includes cross-linked hydroxyphenyl-substituted hyaluronan (HPS-HA), cross-linked hydroxyphenyl-substituted collagen (HPS-C), or both. The cross-linked HPS-HA, cross-linked HPS-C, or both have been formed by cross-linking of hydroxyphenyl groups of HPS-HA, HPS-C, or both to form dihydroxyphenyl bridges. Also disclosed are methods for repair of tissue damage in a subject in need thereof. The methods include surgically implanting the biocompatible tissue graft into a site of the tissue damage in the subject.
Public/Granted literature
- US20160058534A1 BIOCOMPATIBLE TISSUE GRAFT Public/Granted day:2016-03-03
Information query
IPC分类: