Invention Grant
- Patent Title: Method of preventing or treating skin necroptosis disease comprising RIP3-MLKL pathway blocker
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Application No.: US15017470Application Date: 2016-02-05
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Publication No.: US10004736B2Publication Date: 2018-06-26
- Inventor: You Sun Kim
- Applicant: Ajou University Industry-Academic Cooperation Foundation
- Applicant Address: KR Gyeonggi-do
- Assignee: Ajou University Industry-Academic Cooperation Foundation
- Current Assignee: Ajou University Industry-Academic Cooperation Foundation
- Current Assignee Address: KR Gyeonggi-do
- Agency: Morrison & Foerster LLP
- Priority: KR10-2015-0061012 20150430
- Main IPC: A61K31/506
- IPC: A61K31/506 ; A61K31/635 ; A61K38/06 ; A61K31/45 ; G01N33/68 ; A61K45/06 ; A61K31/4178
Abstract:
The present invention relates to methods of preventing or treating skin necroptosis diseases, including administering to subjects receptor-interacting protein kinase-3 (RIP3)-mixed lineage kinase domain-like protein (MLKL) pathway blockers or dabrafenib, and method of diagnosing of skin necroptosis diseases, including detecting phosphorylated MLKL. The RIP3-MLKL pathway blockers according to the present invention directly suppress RIP3 overexpressing in skin necroptosis diseases, or inhibit phosphorylation and translocation to plasma membranes of MLKL, subsequently induced therefrom, thereby effectively preventing skin cell death via necroptosis. Thus, the present invention can prevent or treat a variety of skin diseases caused by necroptosis.
Public/Granted literature
- US20160317535A1 METHOD OF PREVENTING OR TREATING SKIN NECROPTOSIS DISEASE COMPRISING RIP3-MLKL PATHWAY BLOCKER Public/Granted day:2016-11-03
Information query
IPC分类:
