Invention Grant
- Patent Title: Process for drying of BIBW2992, of its salts and of solid pharmaceutical formulations comprising this active ingredient
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Application No.: US15371252Application Date: 2016-12-07
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Publication No.: US10004743B2Publication Date: 2018-06-26
- Inventor: Albert Barta
- Applicant: Boehringer Ingelheim International GmbH
- Applicant Address: DE Ingelheim am Rhein
- Assignee: Boehringer Ingelheim International GmbH
- Current Assignee: Boehringer Ingelheim International GmbH
- Current Assignee Address: DE Ingelheim am Rhein
- Agent Marc A. Began; Atabak R. Royaee
- Priority: EP09164659 20090706; EP10154562 20100224
- Main IPC: A61K31/4375
- IPC: A61K31/4375 ; A61K9/00 ; A61K9/28 ; A61K31/517 ; A61K9/16 ; A61K9/20
Abstract:
The present invention relates to a drying process of BIBW 2992 or the salts thereof, preferably the dimaleate salt, as well as of solid pharmaceutical formulations comprising BIBW2992 or a salt thereof, and to pharmaceutical compositions comprising BIBW 2992 or a salt thereof as the active product ingredient, characterized by a water activity of the formulation of not more than 0.20 or a water content (Karl-Fischer) of not more than 4.2%.
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