Invention Grant
- Patent Title: Use of inhibitors of Bruton's tyrosine kinase (Btk)
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Application No.: US15659803Application Date: 2017-07-26
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Publication No.: US10004746B2Publication Date: 2018-06-26
- Inventor: Joseph J. Buggy , Laurence Elias , Gwen Fyfe , Eric Hedrick , David J. Loury , Tarak D. Mody
- Applicant: Pharmacyclics LLC
- Applicant Address: US CA Sunnyvale
- Assignee: Pharmacyclics LLC
- Current Assignee: Pharmacyclics LLC
- Current Assignee Address: US CA Sunnyvale
- Agency: Foley Hoag LLP
- Agent Hathaway P. Russell; Lucas P. Watkins
- Main IPC: A61K31/519
- IPC: A61K31/519 ; A61K31/195 ; A61K31/337 ; A61K31/4184 ; A61K31/436 ; A61K31/437 ; A61K31/454 ; A61K31/4745 ; A61K31/475 ; A61K31/573 ; A61K31/606 ; A61K31/664 ; A61K31/704 ; C07D487/04 ; A61K39/395 ; A61K9/06 ; A61K31/7076 ; A61K31/7032 ; A61K31/69 ; A61K31/675
Abstract:
Disclosed herein are methods for treating a cancer comprising: a. administering a Btk inhibitor to a subject sufficient to result in an increase or appearance in the blood of a subpopulation of lymphocytes defined by immunophenotyping; b. determining the expression profile of one or more biomarkers from one or more subpopulation of lymphocytes; and c. administering a second agent based on the determined expression profile.
Public/Granted literature
- US20180015091A1 USE OF INHIBITORS OF BRUTON'S TYROSINE KINASE (BTK) Public/Granted day:2018-01-18
Information query
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