Invention Grant
- Patent Title: Tolerogenic synthetic nanocarriers for generating CD8+ regulatory T cells
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Application No.: US13457936Application Date: 2012-04-27
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Publication No.: US10004802B2Publication Date: 2018-06-26
- Inventor: Takashi Kei Kishimoto , Christopher Fraser , Roberto A. Maldonado
- Applicant: Takashi Kei Kishimoto , Christopher Fraser , Roberto A. Maldonado
- Applicant Address: US MA Watertown
- Assignee: Selecta Biosciences, Inc.
- Current Assignee: Selecta Biosciences, Inc.
- Current Assignee Address: US MA Watertown
- Agency: Wolf, Greenfield & Sacks, P.C.
- Main IPC: A61K47/68
- IPC: A61K47/68 ; A61K39/00 ; C07K16/18 ; A61K9/51 ; A61K9/58 ; A61K47/00 ; A61K9/14 ; A61K39/385 ; A61K39/35 ; G01N33/50 ; G01N33/569 ; B82Y5/00 ; A61K39/36 ; A61K9/127 ; A61K38/38 ; A61K31/192 ; A61K38/13 ; A61K38/18 ; A61K47/50 ; A61K47/52 ; A61K47/54 ; A61K47/59 ; A61K47/64 ; A61K47/69 ; B82Y40/00
Abstract:
Disclosed are synthetic nanocarrier methods, and related compositions, comprising administering MHC Class I-restricted and/or MHC Class II-restricted epitopes of an antigen and immunosuppressants in order to generate tolerogenic immune responses against the antigen, such as the generation of antigen-specific CD8+ regulatory T cells.
Public/Granted literature
- US20120276155A1 TOLEROGENIC SYNTHETIC NANOCARRIERS FOR GENERATING CD8+ REGULATORY T CELLS Public/Granted day:2012-11-01
Information query
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