Invention Grant
![Substituted 6,7-dihydropyrazolo[1,5-a] pyrazines as negative allosteric modulators of mGlUR2 receptors](/docs/US/2018-06-26/US10005785B2/abs.jpg.600x600.jpg)
- Patent Title: Substituted 6,7-dihydropyrazolo[1,5-a] pyrazines as negative allosteric modulators of mGlUR2 receptors
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Application No.: US15500319Application Date: 2015-07-30
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Publication No.: US10005785B2Publication Date: 2018-06-26
- Inventor: Sergio-Alvar Alonso-de Diego , Michiel Luc Maria Van Gool , Maria Luz Martin-Martin , Susana Conde-Ceide , José Ignacio Andrés-Gil , Óscar Delgado-González , Gary John Tresadern , Andrés Avelino Trabanco-Suárez
- Applicant: Janssen Pharmaceutica NV
- Applicant Address: BE
- Assignee: Janssen Pharmaceutica NV
- Current Assignee: Janssen Pharmaceutica NV
- Current Assignee Address: BE
- Priority: EP14179600 20140801; EP14196083 20141203
- International Application: PCT/EP2015/067572 WO 20150730
- International Announcement: WO2016/016395 WO 20160204
- Main IPC: A61K31/4985
- IPC: A61K31/4985 ; C07D487/04 ; A61K9/00 ; A61K9/06 ; A61K9/10 ; A61K9/20 ; A61K31/501 ; A61K31/506
![Substituted 6,7-dihydropyrazolo[1,5-a] pyrazines as negative allosteric modulators of mGlUR2 receptors](/abs-image/US/2018/06/26/US10005785B2/abs.jpg.150x150.jpg)
Abstract:
The present invention relates to novel 6,7-dihydropyrazolo[1,5-a]pyrazin-4(5H)-one derivatives of Formula (I) as negative allosteric modulators (NAMs) of the metabotropic glutamate receptor subtype 2 (“mGluR2”). The invention is also directed to pharmaceutical compositions comprising such compounds, to processes for preparing such compounds and compositions, and to the use of such compounds and compositions for the prevention or treatment of disorders in which the mGluR2 subtype of metabotropic receptors is involved.
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