Invention Grant
- Patent Title: O-demethylating process of methoxy substituted morphinan-6-one derivatives
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Application No.: US15302830Application Date: 2015-04-07
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Publication No.: US10005791B2Publication Date: 2018-06-26
- Inventor: Georg Ulrich Weigl , Dominik Stefan Stämpfli , Nelli Maurer
- Applicant: CILAG AG
- Applicant Address: CH Neuhausen am Rheinfall
- Assignee: Noramco GmbH
- Current Assignee: Noramco GmbH
- Current Assignee Address: CH Neuhausen am Rheinfall
- Agency: Alston & Bird LLP
- Priority: EP14164132 20140410; EP14186982 20140930
- International Application: PCT/EP2015/057508 WO 20150407
- International Announcement: WO2015/155181 WO 20151015
- Main IPC: C07D489/08
- IPC: C07D489/08
Abstract:
The present invention relates to an improved process for O-demethylating methoxy substituted morphinan-6-one derivatives using AlCl3 as a demethylating agent in a reaction-inert solvent having a water content ranging from 0.1% wt to 0.8% wt. 10.
Public/Granted literature
- US20170022211A1 O-DEMETHYLATING PROCESS OF METHOXY SUBSTITUTED MORPHINAN-6-ONE DERIVATIVES Public/Granted day:2017-01-26
Information query
