Invention Grant
- Patent Title: Double-acylated GLP-1 derivatives
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Application No.: US15346323Application Date: 2016-11-08
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Publication No.: US10005827B2Publication Date: 2018-06-26
- Inventor: Jane Spetzler , Thomas Kruse , Lars Linderoth , Jacob Kofoed
- Applicant: Novo Nordisk A/S
- Applicant Address: DK Bagsvaerd
- Assignee: Novo Nordisk A/S
- Current Assignee: Novo Nordisk A/S
- Current Assignee Address: DK Bagsvaerd
- Agent Rosemarie R. Wilk-Orescan
- Priority: EP11162087 20110412
- Main IPC: A61K38/26
- IPC: A61K38/26 ; A61K47/54 ; C07K14/605 ; A61K47/60 ; A61K38/00

Abstract:
The invention relates to a derivative of a GLP-1 analog, which analog comprises a first K residue at a position corresponding to position 27 of GLP-1(7-37) (SEQ ID NO: 1); a second K residue at a position corresponding to position T of GLP-1(7-37), where T is an integer in the range of 7-37 except 18 and 27; and a maximum of ten amino acid changes as compared to GLP-1(7-37); wherein the first K residue is designated K27, and the second K residue is designated KT; which derivative comprises two albumin binding moieties attached to K27 and KT, respectively, via a linker, wherein the albumin binding moiety comprises a protracting moiety selected from HOOC—(CH2)x—CO— and HOOC—C6H4—O—(CH2)y—CO—; in which x is an integer in the range of 6-16, and y is an integer in the range of 3-17; wherein the linker comprises an element of the formula —NH—(CH2)2—(O—(CH2)2)k—O—(CH2)n—CO—, wherein k is an integer in the range of 1-5, and n is an integer in the range of 1-5; or a pharmaceutically acceptable salt, amide, or ester thereof. The invention also relates to the pharmaceutical use thereof, for example in the treatment and/or prevention of all forms of diabetes and related diseases, as well as to corresponding novel GLP-1 analogs. The derivatives are suitable for oral administration.
Public/Granted literature
- US20170058014A1 Double-Acylated GLP-1 Derivatives Public/Granted day:2017-03-02
Information query
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