Invention Grant
- Patent Title: Anti-IL-4/anti-IL-13 bispecific antibody formulations
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Application No.: US14787507Application Date: 2014-04-29
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Publication No.: US10005835B2Publication Date: 2018-06-26
- Inventor: Sophie Carayon , Otmane Boussif
- Applicant: Sanofi
- Applicant Address: FR Paris
- Assignee: SANOFI
- Current Assignee: SANOFI
- Current Assignee Address: FR Paris
- Agency: Morrison & Foerster LLP
- Priority: EP14305160 20140205
- International Application: PCT/EP2014/058733 WO 20140429
- International Announcement: WO2014/177568 WO 20141106
- Main IPC: C07K16/24
- IPC: C07K16/24 ; A61K39/395 ; A61K47/22 ; A61K47/26 ; C07K16/46 ; A61K39/00

Abstract:
The present invention provides stable pharmaceutical antibody formulations, including lyophilized formulations, comprising an anti-IL-4/anti-IL-13 bispecific antibody and a buffering system, wherein the pH of the formulation is about pH 7, and wherein the formulation has a low salt concentration in order to reduce the ionic strength of the formulation. The formulations may, optionally, further comprise a non-ionic surfactant, a sugar, and/or a non-ionic stabilizing agent. The formulations can be used in the treatment of various diseases.
Public/Granted literature
- US20160075777A1 ANTI-IL-4/ANTI-IL-13 BISPECIFIC ANTIBODY FORMULATIONS Public/Granted day:2016-03-17
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