Invention Grant
- Patent Title: Use of small molecules to enhance MAFA expression in pancreatic endocrine cells
-
Application No.: US14706310Application Date: 2015-05-07
-
Publication No.: US10006006B2Publication Date: 2018-06-26
- Inventor: Alireza Rezania
- Applicant: Janssen Biotech, Inc.
- Applicant Address: US PA Horsham
- Assignee: Janssen Biotech, Inc.
- Current Assignee: Janssen Biotech, Inc.
- Current Assignee Address: US PA Horsham
- Agent Lois A. Gianneschi
- Main IPC: C12N5/071
- IPC: C12N5/071
Abstract:
The present invention provides methods, cell cultures and differentiation media to promote differentiation of pluripotent stem cells to pancreatic endocrine cells of a mature phenotype. The resulting pancreatic endocrine cells express single hormonal insulin, PDX1, NKX6.1, and MAFA. In one or more differentiation stages, culturing may be carried out in a culture vessel at the air-liquid interface.
Public/Granted literature
- US20150329828A1 Use of Small Molecules to Enhance Mafa Expression in Pancreatic Endocrine Cells Public/Granted day:2015-11-19
Information query
