- Patent Title: RNA interference agent, method for producing same, and use therefor
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Application No.: US14648521Application Date: 2013-11-29
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Publication No.: US10006024B2Publication Date: 2018-06-26
- Inventor: Yukio Kitade , Remi Nakashima
- Applicant: GIFU UNIVERSITY
- Applicant Address: JP Gifu-shi
- Assignee: GIFU UNIVERSITY
- Current Assignee: GIFU UNIVERSITY
- Current Assignee Address: JP Gifu-shi
- Agency: Oliff PLC
- Priority: JP2012-261730 20121129
- International Application: PCT/JP2013/082179 WO 20131129
- International Announcement: WO2014/084354 WO 20140605
- Main IPC: C12N15/113
- IPC: C12N15/113 ; C12Q1/68 ; A61K31/7125 ; A61P43/00 ; C12N15/11
Abstract:
Provided is an RNA interference agent, with which a suppression effect on the off-target effect can be obtained with a simple system. The disclosures relate to an RNA interference agent provided with a single-stranded oligonucleotide passenger strand having one or two or more PAZ domain low-affinity units at the 3′-end.
Public/Granted literature
- US20150307878A1 RNA INTERFERENCE AGENT, METHOD FOR PRODUCING SAME, AND USE THEREFOR Public/Granted day:2015-10-29
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