Invention Grant
- Patent Title: Recombinant poxviral vectors expressing both rabies and OX40 proteins, and vaccines made therefrom
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Application No.: US15410588Application Date: 2017-01-19
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Publication No.: US10006050B2Publication Date: 2018-06-26
- Inventor: Teshome Mebatsion , Jules Maarten Minke , Frederic David
- Applicant: MERIAL, INC.
- Applicant Address: US GA Duluth
- Assignee: MERIAL, INC.
- Current Assignee: MERIAL, INC.
- Current Assignee Address: US GA Duluth
- Agency: Merial Inc.
- Agent Judy Jarecki-Black; Richard Seeger
- Main IPC: C12N15/63
- IPC: C12N15/63 ; C12N15/86 ; C12N15/863 ; A61K39/008 ; A61K39/12 ; A61K39/39 ; A61K39/205 ; A61K39/00
Abstract:
The present invention provides vectors that contain and co-express in vivo or in vitro immunogenic polypeptides or antigens together with an OX40L polypeptide, which functions as a genetic adjuvant. Together, the immunogenic polypeptide and the OX40L polypeptide elicit an immune response in animal or human, which is greater than the immune response elicited by the immunogenic polypeptide alone. In a particular example, the invention provides vectors encoding a Rabies G immunogenic polypeptide and a canine OX40L genetic adjuvant, which vectors elicit strong immune responses in canine against rabies virus.
Public/Granted literature
- US20170137843A1 Recombinant Poxviral Vectors Expressing both Rabies and OX40 Proteins, and Vaccines Made Therefrom Public/Granted day:2017-05-18
Information query
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