Invention Grant
- Patent Title: Laglidadg homing endonuclease cleaving the C-C chemokine receptor type-5 (CCR5) gene and uses thereof
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Application No.: US14891202Application Date: 2014-05-28
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Publication No.: US10006052B2Publication Date: 2018-06-26
- Inventor: Jordan Jarjour , Alexander Astrakhan
- Applicant: Cellectis , Precision Genome Engineering, Inc.
- Applicant Address: FR Paris US WA Tumwater
- Assignee: CELLECTIS,PRECISION GENOME ENGINEERING, INC.
- Current Assignee: CELLECTIS,PRECISION GENOME ENGINEERING, INC.
- Current Assignee Address: FR Paris US WA Tumwater
- Agency: Arrigo, Lee, Guttmann & Mouta-Bellum LLP
- Priority: DK201370302 20130531
- International Application: PCT/EP2014/061186 WO 20140528
- International Announcement: WO2014/191525 WO 20141204
- Main IPC: C12N15/90
- IPC: C12N15/90 ; C12N9/22 ; A61K35/17 ; A61K38/46
Abstract:
Disclosed herein are compositions for inactivating the human CCR5 gene comprising engineered LAGLIDADG homing endonucleases (LHEs) and their derivatives, particularly derived from members of the \-Onul subfamily of LHE. Polynucleotides encoding such endonucleases, vectors comprising said polynucleotides, cells comprising or having been treated with such endonucleases, and therapeutic compositions deriving therefrom are also provided.
Public/Granted literature
- US20160102323A1 A LAGLIDADG HOMING ENDONUCLEASE CLEAVING THE C-C CHEMOKINE RECEPTOR TYPE-5 (CCR5) GENE AND USES THEREOF Public/Granted day:2016-04-14
Information query
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