Invention Grant
- Patent Title: Methods for control of flux in metabolic pathways through enzyme relocation
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Application No.: US14620054Application Date: 2015-02-11
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Publication No.: US10006062B2Publication Date: 2018-06-26
- Inventor: James R. Swartz
- Applicant: The Board of Trustees of the Leland Stanford Junior University , GreenLight Biosciences, Inc.
- Applicant Address: US CA Stanford US MA Medford
- Assignee: The Board of Trustees of the Leland Stanford Junior University,GreenLight Biosciences, Inc.
- Current Assignee: The Board of Trustees of the Leland Stanford Junior University,GreenLight Biosciences, Inc.
- Current Assignee Address: US CA Stanford US MA Medford
- Agency: Wolf, Greenfield & Sacks, P.C.
- Main IPC: C12P1/00
- IPC: C12P1/00 ; C12P7/42 ; C12N9/10 ; C12N9/88 ; C12N15/62 ; C12P7/16 ; C12P7/62 ; C12P23/00 ; C12N15/70 ; C12P5/00
Abstract:
Genetically manipulated cells, lysates of such cells, systems, and methods of use thereof are provided, where one or more enzymes in a pathway of interest are genetically modified to incorporate a peptide sequence that provides for relocation of the protein, e.g., to the periplasm, so as to sequester the enzyme, and where the enzyme controls flux in the pathway of interest.
Public/Granted literature
- US20150191753A1 METHODS FOR CONTROL OF FLUX IN METABOLIC PATHWAYS THROUGH ENZYME RELOCATION Public/Granted day:2015-07-09
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